Posted by Pamela Nathan on September 05, 2017
Microbiota play a key role in various body functions that include physiological, metabolic, and immunological processes. Now we know that alteration in the gut microbiota can influence infectious and non-infectious diseases.
In patients with human immunodeficiency virus (HIV), even those who control their disease with antiretroviral drugs (ART), their gut microbiome is very different to the microbiome of those not infected with HIV.
New information is pointing to these patients having a gut 'dysbiosis' that may lead to a breakdown in the gut immunologic activity which in turn causes systemic bacteria diffusion and inflammation.
Now we are looking at the ability of probiotics to modulate epithelial barrier functions, microbiota composition, and microbial translocation.
Read this mini-review that analyzes the use of probiotics to prevent and attenuate several gastrointestinal manifestations and to improve gut-associated lymphoid tissue (GALT) immunity in HIV infection.