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How Is Gut Health Linked to Brain Inflammation in People With HIV?

Recent good news! 

A grant from the Campbell Foundation helps researchers find answers to the questions as they explore HIV-associated neurocognitive disorders (HAND).

The Campbell Foundation has granted $77,495 to Cristina Granziera, MD, PhD, of Massachusetts General Hospital. She is responsible for researching the relationship between the gut and the brain in people living with HIV.

Cristina Granziera and her team are hoping to find out whether an imbalance in the gut microbiomes are associated with an increase of inflammation of the brain.

This is a very significant area of interest as inflammation of the brain can lead to HIV-associated neurocognitive disorders (HAND). These disorders often go undiagnosed and may possibly result in problems with thinking, memory and mood.

A press release by the Campbell Foundation states that the researchers will accomplish the study by making use of noninvasive imaging (magnetic resonance imaging and positron emission tomography).

Granziera says in the press release, “Although antiretroviral therapy has dramatically improved the lives of HIV-positive individuals, nearly half of those who achieve viral suppression continue to suffer from HIV-associated neurocognitive disorders (HAND)."

"Demonstrating the existence of a pathological gut-brain relationship in HIV-infected patients may open new perspectives to diminish the pathological consequences of HIV infection on the brain through the modulation of composition of gut microbiota (i.e. with changes in diet, use of prebiotics, fecal microbiota transplantation etc.) or supplementation of microbiota products.”



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